产品货号：
Z16951
中文名称：
GLS2抗体
英文名称：
Anti-GLS2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-GLS2 Antibody |
| 指标别名 | GLS2;GA;Glutaminase liver isoform;mitochondrial;GLS;EC 3.5.1.2;L-glutaminase;L-glutamine amidohydrolase |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | GLS2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | GLS2 antibody was raised against an 18 amino acid synthetic peptide near the center terminus of human GLS2.The immunogen is located within amino acids 300 - 350 of GLS2. |
| 计算分子量 | 66kDa |
| 成分 | GLS2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | GLS2 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | GLS2 antibody can be stored at 4℃ up to one year.Antibodies should not be exposed to prolonged high temperatures. |
| 背景资料 | Phosphate-activated glutaminase,also known as Glutaminase 2 (GLS2),was initially isolated from rat liver,although it has been shown to be expressed in other tissues.Like the functionally similar,larger kidney glutaminase,GLS2 catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia.Expression of GLS2 is increased by p53 under both stressed and nonstressed conditions,resulting in increased levels of glutamate and alpha-ketoglutarate,which in turn results in enhanced mitochondrial respiration and ATP generation.GLS2 also regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing ROS-levels,suggesting that GLS2 acts as a mediator of p53's role in antioxidant defense in addition to its role in energy metabolism. |
| Uniprot ID | Q9UI32 |
| 基因名全称 | Glutaminase 2 (liver,mitochondrial) |
| 蛋白名全称 | Glutaminase 2 (liver,mitochondrial) |
| 推荐稀释比 | GLS2 antibody can be used for detection of GLS2 by Western blot at 0.5 ～ 1μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in rat samples;Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse and rat samples.All other applications and species not yet tested. |
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